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KMID : 0370219980420030243
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Yakhak Hoeji
1998 Volume.42 No. 3 p.243 ~ p.247
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Determination of Chlorpromazine Using Plasticizers as Extraction Solvent
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이지연/Lee JY
정문모/허문회/안문규/Jung MM/Hur MH/Ahn MK
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Abstract
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A method for the determination of basic drugs based on their reaction with picric acid to form an ion-association complex extractable into several plasticizers was developed. Ba sic drugs-picric acid complexes in acid medium could be extracted quantitatively into several plasticizers except phosphates. For example, the chlorpromazine-picric acid complex showed maximum absorbance at near 410nm and was applied to extraction spectrophotometric determination of chlorpromazine. The calibration curves are linear (r>0.998) within a range from 10-6 to 5 X 10-4M and the precision of the method was acceptable because RSD was less than 2.6% (n=7). The factors affecting the extraction system was discussed.
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KEYWORD
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